Research interest

We are interested in functional genomics; particularly we study the resistance to biotic and abiotic stresses, the molecular physiology of tropical fruit ripening, we work on molecular breeding for the agro export industry and in medicinal plants. Now the GRU is the Peruvian counterpart of the potato genome sequencing consortium.

Resources and facilities

We are initiating the setup of a genomics research unit, so far we count with all the facilities of a normal molecular biology laboratory.



Relevant publications

Visser RGF, Bachem CWB, de Boer JM, Bryan GJ, Chakrabati SK, Feingold SE, Gromadka R, van Ham RCHJ, Huang S, Jacobs JME, Kuznetsov B, de Melo PE, Milbourne D, Orjeda G, Sagredo B, Tang X. (2009). Sequencing the Potato Genome: Outline and First Results to Come from the Elucidation of the Sequence of the World's Third Most Important Food Crop.

Rossi C, Cuesta-Marcos A, Vales I, Gomez-Pando L, Orjeda G , Wise R, Sato K, Hori K and Hayes P. (2006) Testing the effectiveness of barley stripe rust resistance QTL detected in Mexico and the USA against a possible new race in Peru and mapping of genes conferring resistance to leaf rust and mildew in the same population. Subbmit to Molecular Breeding.

Nieto C*, Morales M*, Orjeda G* , Clepet C, Truniger V, Sturbois B, Caboche M, García-Mas J, Aranda MA and Bendahmane A. (2006) An eIF4E allele confers resistance against an uncapped and non-polyadinilated RNA carmovirus.* equal first authorship

Morales M* , Orjeda G*, Nieto N, van Leeuwen H, Monfort A, Charpentier M, Caboche M, Arús P, Puigdomènech P, Aranda MA, Dogimont C, Bendahmane A and Garcia-Mas J. (2005) Physical map covering the Nsv locus that confers resistance to Melon necrotic spot virus in melon ( Cucumis melo L.). Theoretical and Applied Genetics 11 ( 5):  914-922. * equal first authorship

International Rice Genome Sequencing Project. (2005) The map based sequence of the rice genome. Nature 436:793-800.

Clark D, Rowlett RS, Coleman JR and Klessig DF. (2004) Complementation of the yeast deletion mutant DNCE103 by members of the b class of carbonic anhydrases is dependent on carbonic anhydrase activity rather than an antioxidant activity. Biochemical J . 379: 609-615.

Gidekel M*, Destefano-Beltrán L*, Garcia P, Fuentes L, Alberdi M, Bravo L, Corcuera L and Gutierrez A. (2003) Identification and characterization of three novel cold-acclimation responsive genes from the extremophile hair grass Deschampsia antarctica Desv. Extremophiles 7: 459-469. *Equal first authorship.

Becerra Lopez-Lavalle LA and Orjeda G. (2002) Occurrence and Cytological Mechanism of 2n Pollen Formation in a Tetraploid Accession of Ipomoea batatas (Sweet Potato). Journal of Heredity 93: 185-192. 

Slaymaker DH, Navarre DA, Clark D , del Pozo O, Martin GB and Klessig DF. (2002) The tobacco salicylic acid-binding protein 3 (SABP3) is the chloroplast carbonic anhydrase, which exhibits antioxidant activity and plays a role in the hypersensitive defense response. Proc. Natl. Acad. Sci. USA 99: 11640-11645.

Casas-Mollano A*, Destefano-Beltrán L*. (2000) Characterization of a cDNA encoding a TTG1-like protein from Apple Fruits. Plant Physiol. 122:1457. *Equal first authorship.

Clark D , Durner J, Navarre DA and Klessig D. (2000) Nitric oxide inhibition of tobacco catalase and ascorbate peroxidase. Mol. Plant-Microbe Interact. 13:1380-1384.

Albrecht-Ruíz M, Clark-Leza D and Alemán-Polo M. (1999) Rapid method for biogenic amines evaluation in fish meals. Aquatic Food Prod. Technol. 8: 71-84.

Orjeda G , Escalant JV, Moore N. (1999) The International Musa testing programme (IMTP) phase II. Overview of final report and summary of results. INFO MUSA 8 (1).

León-Velarde F, Richalet JP, Chávez JC, Kacimi R, Rivera-Chira M, Palacios JA and Clark D . (1998) Inter and intra species-related differences in the regulation of the cardiac autonomic system. Comp. Biochem. Physiol. B. Biochem. Mol. Biol. 119: 819-823.

León-Velarde F, Richalet JP, Chávez JC, Kacimi R, Rivera-Chira M, Palacios JA, and Clark D . 1996. Hypoxia and normoxia-induced reversibility of autonomic control in Andean guinea pig heart. J. Appl. Physiol. 81: 2229-2234.

León-Velarde F, de Muizon C, Palacios JA, Clark D and Monge C. (1996) Hemoglobin affinity and structure in high altitude and sea-level carnivores from Perú. Comp. Biochem. Physiol. A. Physiol 113: 407-411.

Destefano-Beltrán L , Van Caeneghem W, Geelan J, Van Montagu M, Van Der Straeten D. (1995) Characterization of three members of the ACC synthase gene family in Solanum tuberosum . Mol Gen Genet . 246: 496-508.

Sarria R, Torres E, Balcázar N, Destefano-Beltrán L and Roca W (1995) Progress in Agrobacterium -mediated transformation of cassava ( Manihot esculenta Crantz). In: The Cassava Biotechnology Network, Proceedings of the Second International Scientific Meeting, Bogor, 22-26 August 1994, Working Document, pp. 241-244, CIAT, Cali, Colombia.

Norelli J, Aldwinckle H, Destefano-Beltrán L , Jaynes J. (1994) Transgenic "Malling 26" apple expressing the attacin E gene has increased resistance to Erwinia amylovora. Euphytica 77: 123-128.

Norelli J, Aldwinckle H, Destefano-Beltrán L , Jaynes J. (1994) Transgenic apple plants containing lytic proteins have increased resistance to Erwinia. Journal of Cellular Biochemistry, Supplement 18A, (p89).

Norelli JL, Aldwinckle HS, Destefano-Beltran L & Jaynes JM. (1994) Transgenic ''Malling 26'' (M7) apple expressing the attacin E gene has increased resistance to Erwinia amylovora. In: Schmidt H & Kellerhals E (eds) Progress in Temperate Fruit Breeding. (pp 333-338) Kluwer Academic Publishers, Dordrecht .

Clark D, Albrecht M and Arévalo J. (1994) Ascorbate variations and dehydroascorbate reductase activity in Trypanosoma cruzi epimastigotes and tripomastigotes. Mol. Biochem. Parasitol. 66: 143-145.

Destefano-Beltrán L , Nagpala P, Cetiner S, Denny T, Jaynes J. (1993) Using genes encoding novel peptides and proteins to enhance disease resistance in plants. In: Biotechnology in Plant Disease Control, 175-189 pp, Ilan Chet (editor), Wiley-Liss, Inc. New York .

Jaynes J, Destefano-Beltrán L , Nagpala P, Cetiner S. (1993) Lytic peptides and their potential for enhancing plant disease resistance. In: Workshop on Engineering Plant against Pests and Pathogens, pp 37-41, Instituto Juan March de Estudios e Investigaciones, Madrid.

Norelli J, Aldwinckle H, Destefano-Beltrán L , Jaynes J. (1993) Increasing the fire blight resistance of apple by transformation with genes encoding antibacterial proteins. Acta Horticulturae 338: 385-386.

Jaynes J, Nagpala P, Destefano-Beltrán L , Huang J, Denny T, Cetiner S, Kim J. (1993) Expression of a Cecropin-B analog in transgenic tobacco confers enhanced resistance to bacterial wilt caused by Pseudomonas solanecearum. Plant Science 89: 43-53.

Mont J, Iwanaga M, Orjeda G and Watanabe K. (1993) Abortion and determination of stages for embryo rescue in crosses between the sweet potato , Ipomoea batatas Lam. (2n=6x =90) and its wild relative, I. trifida (H.B.K.) G. Don. (2n=2x=30). Sexual Plant Reproduction 6(3):176-182.

Hamaker BR, Valles C, Gilman R, Hardmeier RM, Clark D , Garcia HH, Gonzales AE, Kohlstad I, Castro M, Valdivia R, Rodriguez T and Lescano M. (1992) Amino acid and fatty acid profiles of the Inca peanut ( Plukenetia volubilis ). Cereal Chem. 69: 461-463.

Orjeda G , Iwanaga M and Freyre R. (1992) Use of Ipomoea trifida germplasm for sweet potato improvement. 4. Evaluation of storage root initiators. Proceedings of the Conference Sweet Potato Technology for the 21st Century. Tuskegee, Alabama, U.S.A.

Orjeda G , Iwanaga M and Freyre R. (1991) Use of Ipomoea trifida germplasm for sweet potato improvement. 3. Development of 4x interspecific hybrids between Ipomoea batatas (L.) (2n=6x =90) and I. trifida (H.B.K.) G. Don. (2n=2x=30) as storage root initiators for wild species. Theoretical and Applied Genetics 83:159-163.

Destefano-Beltrán L , Nagpala P, Kim J, Dodds J, Jaynes J. (1991) Genetic transformation of potato to enhance nutritional value and confer disease resistance. In: Molecular Approaches to Crop Improvement (Plant Gene Research, Vol. 8), 17-32 pp, E.S. Dennis y D.J. Llewellyn (Eds), Springer-Verlag, Wien.

Destefano-Beltrán L , Nagpala P, Cetiner S, Dodds J, Jaynes J. (1990). Enhancing Bacterial and Fungal Disease Resitance in Plants: Application to Potato. In: Molecular and Cellular Biology of the Potato, 205-221 pp, M. Vayda and W. Park (Eds), C.A.B. International, Wallingford .

Destefano-Beltrán L , Nagpala P, Kim J, Dodds J, Jaynes J. (1990) Use of synthetic genes to enhance nutritional quality and disease resistance: Application to Potato. In: Molecular Methods for Potato Improvement. Report of the Planning Conference on "Application of Molecular Techniques for Potato Germplasm Enhancement, 46-62 pp, International Potato Center , Lima .

Destefano-Beltrán L , Cetiner S, Denny T, Clark C, Dodds J, Jaynes J. (1990) The Introduction into Tobacco and Potato plants of genes which encode some of the natural components of the humoral immune response of Hyalophora cecropia . Journal of Cellular Biochemistry, Supplement 14E, (p316).

Freyre R, Iwanaga M and Orjeda G . (1990). Utilization of Ipomoea trifida germplasm for sweet potato improvement. 1. Development of synthetic hexaploids of I. trifida (H.B.K.) G. Don. by ploidy level manipulations. Genome 34:201-208

Iwanaga M, Freyre R and Orjeda G . (1990) Utilization of Ipomoea trifida germplasm for sweet potato improvement. 2. Fertility of synthetic 6x clones and triploids with 2n gametes of I. trifida (H.B.K.) G. Don, and their interspecific crossability with sweet potato. Genome 34:209-214.

Orjeda G , Freyre R and Iwanaga M. (1989) Production of 2n pollen in diploid Ipomoea trifida a putative wild ancestor of sweet potato. Journal of Heredity 81:462-467.

Croughan T, Destefano-Beltrán L , Chu Q , Jaynes J. (1989) Transformation of rice by direct gene transfer. In: Review of Advances In Plant Biotechnology, 107-114 pp A.Mujeeb-Kazi and L.S. Sitch, Eds. Mexico City.

Jaynes JM, Xanthopoulos K, Destefano-Beltrán L , Dodds JH. (1987) Increasing bacterial disease resistance in plants utilizing antibacterial genes from insects. Bioessays 6: 263-270.


The GRU is happy to receive the application of Peruvian scientists that would like to apply to the repatriation scheme the Universidad Peruana Cayetano Heredia. Young scientists with at least one postdoc experience are welcome.

ICGEB (The International Centre for Genetic Engineering and Biotechnology)
Fontagro (Fondo Regional de Tecnología Agropecuaria)
Concytec (Consejo Nacioal de Ciencia, Tecnología e Innovación Productiva, Perú)
UPCH (Universidad Peruana Cayetano Heredia)

Genomics Research Unit
Universidad Peruana Cayetano Heredia
Relevant Publications
Resources and facilities
Research interest
Financial support
Art in science
Site hosted at: Centro Nacional de Investigaciones Agropecuarias
Julianna Amaro   Undergraduate Student
Carlos Balmaceda   Undergraduate Student
Daniel Clark Group leader
Silvia Davila   Undergraduate Student
Luis Destefano Group Leader
Maria Julia Gonzalez Undergraduate Student
Roberto Lozano Undergraduate Student
Susy Nuñez MSc Student
Gisella Orjeda Head of the Unit
Karina Rubio Undergraduate Student
Grace Velapatiño   Undergraduate Student